{"id":383,"date":"2025-11-15T16:01:41","date_gmt":"2025-11-15T16:01:41","guid":{"rendered":"https:\/\/anhkim.site\/?page_id=383"},"modified":"2025-12-03T12:05:33","modified_gmt":"2025-12-03T12:05:33","slug":"non-canonical-nucleic-acid","status":"publish","type":"page","link":"https:\/\/anhkim.site\/index.php\/non-canonical-nucleic-acid\/","title":{"rendered":"NON CANONICAL NUCLEIC ACID"},"content":{"rendered":"
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Not all DNA<\/em> play by
the same rules! <\/em><\/h2>\n <\/div>\n <\/div>\n
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Our group explores the dynamic world of nucleic acids beyond the familiar B-DNA double helix, exploring how non-canonical DNA and RNA structures influence gene regulation-from transcription to translation and everything in between. <\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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We investigate how these structures are formed, what stabilizes them, and how they interact with cellular machinery to impact diseases. We have established the chemical-induced formation of B-Z junctions with base extrusion to better\n understand their structural and cellular implications. <\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Our group also places strong emphasis on G-quadruplexes (G4s), investigating how they influence genetic regulation in both cancer and viral systems. Our work has unraveled a G4-dependent mechanism of transcriptional regulation, demonstrating\n significant enrichment at oncogenic promoter, where the formation of transcriptional condensates and promoter activation are highly dependent on G4-mediated protein binding. We identified G-quadruplexes as unique and promising druggable\n targets in human cytomegalovirus and SARS-CoV infections. Our on-going work expands G4-targeting strategies across additional viral systems and cancer models. <\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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We are developing new molecular approaches that influence alternative nucleic acid conformations and build versatile platforms that seek to turn the structural “oddities” of the genome into new therapeutic opportunities.<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Recent Publications<\/h2>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n
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1.    Yoo, W., Song, Y.W., Bansal, V. and Kim, K.K., 2025. G-quadruplex-dependent transcriptional regulation by molecular condensation in the Bcl3 promoter. Nucleic Acids Research<\/em>, 53<\/em>(16),\n p.gkaf827.<\/p>\n

2.    Sultan, M., Razzaq, M., Lee, J., Das, S., Kannappan, S., Subramani, V.K., Yoo, W., Kim, T., Lee, H.R., Chaurasia, A.K. and Kim, K.K., 2025. Targeting the G-quadruplex as a novel strategy for developing antibiotics\n against hypervirulent drug-resistant Staphylococcus aureus. Journal of Biomedical Science<\/em>, 32<\/em>(1), p.15.<\/p>\n

3.    Kannappan, S., Jo, K., Kim, K.K. and Lee, J.H., 2024. Utilizing peptide-anchored DNA templates for novel programmable nanoparticle assemblies in biological macromolecules: A review. International Journal of Biological Macromolecules<\/em>, 256<\/em>,\n p.128427.<\/p>\n

4.    Yoo, W., Song, Y.W., Kim, J., Ahn, J., Kim, J., Shin, Y., Ryu, J.K. and Kim, K.K., 2023. Molecular basis for SOX2-dependent regulation of super-enhancer activity. Nucleic Acids Research<\/em>, 51<\/em>(22),\n pp.11999-12019.<\/p>\n

5.    Razzaq, M., Han, J.H., Ravichandran, S., Kim, J., Bae, J.Y., Park, M.S., Kannappan, S., Chung, W.C., Ahn, J.H., Song, M.J. and Kim, K.K., 2023. Stabilization of RNA G-quadruplexes in the SARS-CoV-2 genome\n inhibits viral infection via translational suppression. Archives of pharmacal research<\/em>, 46<\/em>(7), pp.598-615.<\/p>\n

6.    Subramani, V.K. and Kim, K.K., 2023. Characterization of Z-DNA using circular dichroism. In Z-DNA: Methods and Protocols<\/em> (pp. 33-51). New York, NY: Springer US.<\/p>\n

7.    Ravichandran, S., Razzaq, M., Parveen, N., Ghosh, A. and Kim, K.K., 2021. The effect of hairpin loop on the structure and gene expression activity of the long-loop G-quadruplex. Nucleic acids research<\/em>, 49<\/em>(18),\n pp.10689-10706.<\/p>\n

8.    Hur, J.H., Kang, C.Y., Lee, S., Parveen, N., Yu, J., Shamim, A., Yoo, W., Ghosh, A., Bae, S., Park, C.J. and Kim, K.K., 2021. AC-motif: a DNA motif containing adenine and cytosine repeat plays a role in gene\n regulation. Nucleic Acids Research<\/em>, 49<\/em>(17), pp.10150-10165.<\/p>\n

9.    Shamim, A., Razzaq, M. and Kim, K.K., 2020. MD-TSPC4: computational method for predicting the thermal stability of I-motif. International Journal of Molecular Sciences<\/em>, 22<\/em>(1), p.61.<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

Not all DNA play by the same rules! Our group explores the dynamic world of nucleic acids beyond the familiar B-DNA double helix, exploring how non-canonical DNA and RNA structures influence gene regulation-from transcription to translation and everything in between.  We investigate how these structures are formed, what stabilizes them, and how they interact with […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/full-width-page.php","meta":{"footnotes":""},"class_list":["post-383","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/anhkim.site\/index.php\/wp-json\/wp\/v2\/pages\/383","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/anhkim.site\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/anhkim.site\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/anhkim.site\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/anhkim.site\/index.php\/wp-json\/wp\/v2\/comments?post=383"}],"version-history":[{"count":9,"href":"https:\/\/anhkim.site\/index.php\/wp-json\/wp\/v2\/pages\/383\/revisions"}],"predecessor-version":[{"id":1656,"href":"https:\/\/anhkim.site\/index.php\/wp-json\/wp\/v2\/pages\/383\/revisions\/1656"}],"wp:attachment":[{"href":"https:\/\/anhkim.site\/index.php\/wp-json\/wp\/v2\/media?parent=383"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}