Structural pathogenesis is an area to study the developement of a disease by providing structural explanation on the mechanism of cellular processes associated with the disease. The pathogenesis of the infectious disease caused by bacteria and virus are being studied in our laboratory. Current projects deal with the quorum sensing and type III and IV secretion systems in bacteria and Z-DNA binding proteins of several viruses. In addition, structural proteomics study of Helicobacter pylori, which causes probably the most common chronic bacterial infection in stomach is on the progress. Structural analyses of some selected proteins in H. pylori will give the clues to understand the structural basis of this infectious diseases and be the starting point for structure-based development of drug candidates.
Recent Publications
1. Sultan, M., Razzaq, M., Lee, J., Das, S., Kannappan, S., Subramani, V.K., Yoo, W., Kim, T., Lee, H.R., Chaurasia, A.K. and Kim, K.K., 2025. Targeting the G-quadruplex as a novel strategy for developing antibiotics against hypervirulent drug-resistant Staphylococcus aureus. Journal of Biomedical Science, 32(1), p.15.
2. Sultan, M., Arya, R., Chaurasia, A.K. and Kim, K.K., 2023. Sensor histidine kinases kdpD and aauS regulate biofilm and virulence in Pseudomonas aeruginosa PA14. Frontiers in cellular and infection microbiology, 13, p.1270667.
3. Arya, R., Kim, T., Youn, J.W., Bae, T. and Kim, K.K., 2023. Identification of an antivirulence agent targeting the master regulator of virulence genes in Staphylococcus aureus. Frontiers in Cellular and Infection Microbiology, 13, p.1268044.
4. Sultan, M., Arya, R., Chaurasia, A.K. and Kim, K.K., 2023. Sensor histidine kinases kdpD and aauS regulate biofilm and virulence in Pseudomonas aeruginosa PA14. Frontiers in cellular and infection microbiology, 13, p.1270667.
5. Sultan, M., Arya, R. and Kim, K.K., 2021. Roles of two-component systems in Pseudomonas aeruginosa virulence. International journal of molecular sciences, 22(22), p.12152.
6. Batool, N., Shamim, A., Chaurasia, A.K. and Kim, K.K., 2021. Genome-wide analysis of Staphylococcus aureus sequence type 72 isolates provides insights into resistance against antimicrobial agents and virulence potential. Frontiers in microbiology, 11, p.613800.
7. Batool, N., Yoon, S., Imdad, S., Kong, M., Kim, H., Ryu, S., Lee, J.H., Chaurasia, A.K. and Kim, K.K., 2021. An antibacterial nanorobotic approach for the specific targeting and removal of multiple drug‐resistant Staphylococcus aureus. Small, 17(20), p.2100257.
8. Batool, N., Ko, K.S., Chaurasia, A.K. and Kim, K.K., 2020. Functional identification of serine hydroxymethyltransferase as a key gene involved in lysostaphin resistance and virulence potential of Staphylococcus aureus strains. International Journal of Molecular Sciences, 21(23), p.9135.